Pipeline

TTI-101 is an orally bioavailable, small-molecule inhibitor of signal transducer and activator of transcription 3 (STAT3), a transcription factor whose upregulation and activation governs many hallmarks of cancer, inflammation, and fibrosis. Preclinically, TTI-101 has demonstrated an excellent pharmacokinetic profile, potency in attenuating pY705-STAT3 phosphorylation, and efficacy in inhibiting tumor growth in xenograft and syngeneic tumor models. To date, TTI-101 is well tolerated and has clinical activity in a first-in-man Phase 1 study in patients with advanced solid tumors.

For more information on the ongoing clinical trials of TTI-101, please visit our clinical trials page.

TTI-109 is Tvardi’s newest STAT3 inhibitor and is completing IND-enabling studies. TTI-109 is structurally related to, yet chemically distinct from TTI-101, and has demonstrated key characteristics for clinical use including tolerability, bioavailability, and potency.

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